QIAGEN reports results for third quarter and first nine months of 2014
Oct 29 2014

QIAGEN reports results for third quarter and first nine months of 2014

  • Achieved Q3 2014 targets: Adjusted net sales of $336.8 million (+4% CER); adjusted operating income of $84.8 million, a 25% margin; and adjusted EPS of $0.27
  • Adjusted net sales rise approximately 10% CER excluding U.S. HPV business
  • Growth drivers contribute about 30% of total sales, delivering more than 20% CER growth and creating solid foundation for future expansion
  • Free cash flow rises 18% to $72 million
  • QIAGEN reaffirms 2014 expectations for higher adjusted net sales and earnings

Venlo, The Netherlands, October 29, 2014 – QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) announced results of operations for the third quarter and first nine months of 2014, reaffirming full-year expectations announced in January 2014 for improvements in adjusted net sales and earnings.

“QIAGEN again delivered growth in adjusted net sales and earnings in the third quarter of 2014, and is on track to achieve our full-year goals. Our teams are executing on plans to deliver innovation and growth with many new products advancing toward launch in 2015 that will create opportunities across our entire spectrum of customers from life sciences research to clinical diagnostics,” said Peer M. Schatz, Chief Executive Officer of QIAGEN N.V.

“Our growth drivers, now providing about 30% of total sales, are delivering increases at a strong double-digit pace and creating a solid foundation for further expansion. The modular QIAsymphony platform is set to reach 1,250 cumulative placements in 2014, with its superior capabilities and the growing content menu as key drivers for customers. Personalized Healthcare advanced in the third quarter as well, fueled by new FDA-approved and CE-marked companion diagnostics as well as a significant increase in new co-development projects, including ones involving the use of liquid biopsies. Our QuantiFERON-TB diagnostic is gaining broad adoption as the new ‘gold standard’ for detecting latent tuberculosis infections. Our bioinformatics portfolio is being expanded with new capabilities for analysis and interpretation of complex molecular data, addressing this major roadblock to broad adoption of next-generation sequencing technologies in translational research and clinical healthcare settings. We are determined to deliver on our goals for 2014, overcoming the headwind of reduced U.S. sales for our HPV test and preparing for more innovation and growth as well as exciting new product launches in 2015.”

Third quarter 2014 results

Change

In $ millions, except per share information

Q3 2014

Q3 2013

$

CER

Net sales, adjusted

336.8

323.8

4%

4%

Operating income, adjusted

84.8

79.5

7%

 

Net income, adjusted

66.0

62.3

6%

 

Diluted EPS, adjusted

$0.27

$0.26

 

 

Diluted EPS CER, adjusted

$0.27

$0.26

 

 

For information on adjusted figures, please refer to the reconciliation table accompanying this release. Adjusted net sales is a non-GAAP measure that includes all revenue contributions from Ingenuity (acquired April 29, 2013), CLC bio (acquired August 22, 2013) and BIOBASE (acquired April 3, 2014).  Adjusted results for 2013 have also been restated with QIAGEN’s policy as of January 2014 to no longer adjust for restructuring costs and share-based compensation.

Adjusted net sales rose 4% at constant exchange rates (CER) in the third quarter of 2014, driven by higher sales of consumables and related revenues (+3% CER, 87% of sales) and instruments (+11% CER, 13% of sales), as well as improved results in the Molecular Diagnostics, Applied Testing and Pharma customer classes. About one percentage point of total CER growth came from the bioinformatics acquisitions of CLC bio (as of August 22, 2013) and BIOBASE (as of April 3, 2014), and three percentage points from the rest of the business. Currency movements had no tangible impact on reported net sales growth. Excluding sales of U.S. HPV test products in both periods, adjusted net sales rose 10% CER in the third quarter of 2014.

Operating income in the third quarter of 2014 was $50.3 million, up 46% from $34.4 million in the same period of 2013, which included one-time charges for completion of productivity initiatives. Adjusted operating income, which excludes items such as business integration, acquisition-related costs and amortization of intangible assets acquired in business combinations, rose 7% to $84.8 million in the 2014 quarter from $79.5 million a year ago, as the adjusted operating income margin remained at 25% of adjusted net sales. Net income attributable to owners of QIAGEN N.V. was $34.7 million, or $0.14 per diluted share (based on 241.4 million diluted shares) in the third quarter of 2014 compared to $40.7 million, or $0.17 per share (based on 242.4 million diluted shares) in the year-ago period. Results for the third quarter of 2014 included approximately $0.03 of dilution related to the convertible bond transactions completed in March 2014. Adjusted net income rose 6% to $66.0 million, or $0.27 per share ($0.27 CER per share), from $62.3 million, or $0.26 per share.

“QIAGEN’s results for the third quarter and the first nine months of 2014 met our targets and provided a healthy financial position to support the ongoing business expansion,” said Roland Sackers, Chief Financial Officer of QIAGEN N.V. “We are reaffirming our targets of higher adjusted sales and earnings for the full year. In pursuit of our commitment to disciplined capital allocation, we initiated our third $100 million share repurchase program during the quarter and will take similar programs under consideration in the future.”

First nine months 2014 results

Change

In $ millions, except per share information

9M 2014

9M 2013

$

CER

Net sales, adjusted

985.4

943.7

4%

4%

Operating income, adjusted

240.8

222.8

8%

 

Net income, adjusted

180.6

166.5

8%

 

Diluted EPS, adjusted

$0.75

$0.69

 

 

Diluted EPS CER, adjusted

$0.75

$0.69

 

 

For information on adjusted figures, please refer to the reconciliation table accompanying this release. Adjusted net sales is a non-GAAP measure that includes all revenue contributions from Ingenuity (acquired April 29, 2013), CLC bio (acquired August 22, 2013) and BIOBASE (acquired April 3, 2014).  Adjusted results for 2013 have also been restated with QIAGEN’s policy as of January 2014 to no longer adjust for restructuring costs and share-based compensation.

In the first nine months of 2014, adjusted net sales rose 4% at constant exchange rates (CER) on improving results in all customer classes and regions as well as higher sales of consumables and related revenues (+4% CER, 88% of sales) and instruments (+3% CER, 12% of sales). Total CER growth included about two percentage points from the bioinformatics acquisitions of Ingenuity (as of April 29, 2013), CLC bio (as of August 22, 2013) and BIOBASE (as of April 3, 2014), and about two percentage points from the rest of the business. Currency movements had no tangible impact on reported net sales growth. Excluding sales of U.S. HPV test products, adjusted net sales rose 9% CER in the first nine months of 2014.

Operating income in the first nine months of 2014 was $140.3 million compared to $29.3 million in the same period of 2013, which included one-time charges for completion of productivity initiatives. Adjusted operating income, which excludes items such as business integration, acquisition-related costs and amortization of intangible assets acquired in business combinations, rose 8% to $240.8 million from $222.8 million, as the adjusted operating income margin remained at 24% of sales compared to the same period in 2013. Net income attributable to owners of QIAGEN N.V. was $90.8 million, or $0.38 per diluted share (based on 241.7 million diluted shares) in the first nine months of 2014 compared to $8.9 million, or $0.04 per share (based on 241.4 million diluted shares) in the year-ago period. Results for the first nine months of 2014 included approximately $0.09 of dilution related to the convertible bond transactions completed in March 2014. Adjusted net income rose 8% to $180.6 million, or $0.75 per share ($0.75 CER per share), from $166.5 million, or $0.69 per share.

At September 30, 2014, cash and cash equivalents rose to $484.2 million from $330.3 million at December 31, 2013, mainly due to proceeds from convertible notes transactions completed in the first half of 2014. Net cash provided by operating activities in the first nine months of 2014 was $208.9 million compared to $176.8 million in the same period of 2013, with free cash flow of $148.7 million in the 2014 period compared to $120.9 million a year ago. Net cash used in investing activities was $280.8 million, up from $237.1 million a year ago. Net cash generated from financing activities was $230.5 million in the first nine months of 2014 compared to cash used in financing activities of $49.8 million in the same period of 2013.

Business review

Geographic regions

In the third quarter of 2014, the Europe / Middle East / Africa region (+13% CER / 33% of sales) led the performance on improving results in particular in the Nordic region and Turkey. The Americas (-3% CER / 47% of sales) was impacted by the expected decline in revenues related to HPV testing solutions, as well as lower sales in Brazil and Mexico due to the timing of national tenders. The Asia-Pacific / Japan region (+6% CER / 19% of sales) delivered double-digit CER growth in China, and also improvements in Japan and South Korea. Sales in the top seven emerging markets (-1% CER / 14% of sales) were hampered by lower sales in Russia, Brazil and Mexico offsetting gains in China, South Korea, Turkey and India.

Product categories

Consumables and related revenues (Q3 2014: +3% CER, 87% of sales) benefited from gains in Applied Testing, Molecular Diagnostics and Pharma, while Academia was stable compared to the third quarter of 2013. Contributions from the bioinformatics portfolio acquired during 2013 and 2014 supported results in all customer classes. In the first nine months of 2014, consumables and related revenues rose 4% CER and provided 88% of sales.

Instruments (Q3 2014: +11% CER, 13% of sales) grew at a double-digit CER pace in Molecular Diagnostics, and at solid single-digit CER rates in Pharma and Applied Testing, which more than offset a modest decline in Academia. In the first nine months of 2014, instrument sales (which also include instrument service revenues) rose 3% CER and provided 12% of sales.

Customer classes

An overview of performance in QIAGEN’s four customer classes (based on adjusted net sales):

Molecular Diagnostics (Q3 2014: +6% CER, 52% of sales) advanced on the ongoing solid expansion of QIAGEN’s growth drivers, overcoming the expected decline in U.S. HPV test product sales (-46%, 6% of sales) and helping to deliver +19% CER from the rest of the portfolio. The QuantiFERON-TB latent tuberculosis test delivered strong gains in the U.S. and Europe, in line with a 20% CER annual growth rate, and remains on track to exceed $100 million of sales in 2014. Profiling consumables rose more than 20% CER, benefiting from the growing installed base of the QIAsymphony automation system and the related menu expansion in Europe and the U.S. Personalized Healthcare sales also advanced at a solid double-digit CER pace on improving demand for companion diagnostic assays and significantly higher revenues from pharmaceutical co-development projects in the third quarter of 2014. Sales of HPV testing products outside the U.S. declined in the third quarter of 2014, reflecting the impact of timing for national tenders compared to 2013. In the first nine months of 2014, Molecular Diagnostics sales rose 5% CER and provided 51% of sales.

Applied Testing (Q3 2014: +7% CER, 8% of sales) delivered solid single-digit CER sales gains from consumables and instruments, particularly in Human ID / forensics, as well as from expansion of the bioinformatics portfolio to these customers. In the first nine months of 2014, Applied Testing sales also rose 7% CER and provided 8% of sales.

Pharma (Q3 2014: +4% CER, 19% of sales) saw higher instrument sales in the third quarter along with a similar single-digit CER increase in contributions from consumables and bioinformatics, driven by the strongest expansion in the Americas region. In the first nine months of 2014, Pharma sales also rose 4% CER and provided 19% of sales.

Academia (Q3 2014: 0% CER, 21% of sales) experienced a modest decline in instrument sales and largely flat consumable sales compared to the third quarter of 2013, with funding conditions improving modestly in some European countries and the United States during the third quarter of 2014. QIAGEN continues to expect funding levels to improve during the fourth quarter of 2014 and in 2015, but effectively remaining below levels seen in previous years. In the first nine months of 2014, Academia sales rose 1% CER and provided 22% of sales.

Accelerating pace of innovation and growth in 2014

QIAGEN continues to accelerate the pace of innovation and growth in 2014 by executing on targeted initiatives to expand our leadership in addressing the rapidly evolving needs of customers to transform biological samples into valuable molecular insights. Our focus is on these growth drivers: (1) further increasing adoption of the QIAsymphony automation platform and expanding the test menu, (2) extending leadership in Personalized Healthcare with innovative companion diagnostics to guide treatment decisions, (3) establishing the QuantiFERON-TB test as the modern “gold standard” for latent tuberculosis control, (4) expanding the use of QIAGEN bioinformatics to analyze, interpret and report complex biological data; and (5) creating a leading portfolio of universal NGS solutions and complete workflows to drive its adoption in clinical research and diagnostics.

Among recent developments:

QIAsymphony delivering growth in placements as content menu expands 

 After surpassing 1,000 cumulative QIAsymphony placements in 2013, QIAGEN is moving ahead toward achieving its goal of 1,250 cumulative placements by the end of 2014. Approximately 60% of current placements are in Molecular Diagnostic laboratories, and 40% are in the Life Sciences with Applied Testing, Pharma and Academia customers.

The growing installed base of QIAsymphony instruments and expanding content menus are driving double-digit CER growth in related consumables. So far in 2014, seven QIAGEN tests on the Rotor-Gene Q real-time PCR platform, a member of the QIAsymphony family, have been approved by regulators in Europe and/or the United States. QIAGEN is advancing various additional development projects toward regulatory submissions.

Personalized Healthcare leadership gaining further momentum

 A new master collaboration agreement with Astellas Pharma Inc., an R&D-driven global pharmaceutical company headquartered in Japan, aims to develop companion diagnostics paired with Astellas drug candidates in cancer and other diseases. The scope of the agreement can include certain sample types, platforms, indications or biomarkers, thereby giving Astellas access to QIAGEN’s development capabilities for assays based on PCR, NGS and multimodal testing technologies using liquid and tissue biopsies. Two initial projects focus on oncology and diagnostics paired with compounds currently in early clinical development: ASP5878, a fibroblast growth factor receptor (FGFR) inhibitor, and ASP8273, an EGFR inhibitor.

QIAGEN recently submitted a premarket approval (PMA) application to the FDA for U.S. regulatory approval of a companion diagnostic paired with a drug of an undisclosed partner.

QuantiFERON-TB expanding rapidly around the world, launch moving ahead in China

QuantiFERON-TB, the market-leading diagnostic for latent tuberculosis infection, continued to deliver strong growth in the third quarter of 2014 and is on track to surpass $100 million in full-year sales. The launch of this product in China during 2014 is moving ahead quickly, while sales are also expanding in the U.S. and Europe amid significant market conversion opportunities against the 120-year-old skin test. QIAGEN is preparing for commercialization of QuantiFERON-TB Plus, a fourth-generation test for latent TB infection that will deliver an improved clinical profile and further workflow optimization.

Bioinformatics tools driving the advancement of NGS technologies

QIAGEN is driving the growth of its industry-leading bioinformatics portfolio, expanding and integrating the capabilities of its Ingenuity® Variant Analysis™, BIOBASE and CLC Cancer Research Workbench solutions for the analysis, interpretation and reporting of complex genomic data generated through next-generation sequencing. Thousands of researchers have uploaded and analyzed results from more than 250,000 human genomic samples using QIAGEN bioinformatics solutions, further expanding the leading position of QIAGEN’s vast Ingenuity Knowledge Base.

The BIOBASE Human Gene Mutation Database (HGMD®) has been integrated with Ingenuity Variant Analysis, providing comprehensive information on human inherited disease mutations in the Ingenuity Knowledge Base in addition to expertly curated data from the world’s medical and scientific literature.

CLC Cancer Research Workbench has been expanded to detect copy number variations (CNVs) and variants from RNA-seq data. At the recent annual meeting of the American Society of Human Genetics (ASHG), QIAGEN also demonstrated the first “FastQ-to-insight solution,” a new plug-in integrated with Ingenuity Variant Analysis that allows users to identify and interpret somatic cancer driver mutations.

Genomics England, a U.K. collaboration to sequence 100,000 whole genomes from patients and mine the genomic information for insights into diseases and better ways of treatment, has named QIAGEN a winner of its technology assessment. QIAGEN will provide the UK100K project’s researchers with access to Ingenuity® Variant Analysis™.

Innovative NGS workflows and universal solutions helping to address clinical needs 

 QIAGEN’s presence in next-generation sequencing laboratories is expanding with the launch of new “universal” sample and assay technology solutions that are compatible with any sequencing platform. These solutions include sample extraction and purification technologies – especially for cancer tumor samples and single-cell procedures – as well as a portfolio with 14 recently launched GeneRead DNAseq V2 gene panels for targeted enrichment of cancer-related genomic targets.

Development of the sample-to-insight workflow incorporating the GeneReader benchtop NGS sequencer is progressing, with commercialization continuing to be expected in the second half of 2015.

Supporting public health agencies worldwide in the fight against the Ebola virus

Building on its capabilities as the leading provider of diagnostic and surveillance solutions – proven in many outbreaks, including H1N1 and H5N1 influenza, SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) – QIAGEN has taken an active role in the fight against the spread of Ebola. QIAGEN teams are working together with international partners in Africa and around the world to provide a broad range of molecular testing components that are essential for workflows used for detection of this virus. These QIAGEN products – which include the RNeasy and QIAamp® Viral RNA Mini extraction kits as well as the QIAsymphony, QIAcube and EZ1 Advanced instruments – are being used by many laboratories around the world in research and clinical diagnosis settings. QIAGEN products are also essential components of the CDC test protocol and the EZ1-Test protocol used by the U.S. Department of Defense, which received FDA emergency authorization in August 2014. Also in the third quarter of 2014, QIAGEN entered into a partnership with Hamburg-based altona Diagnostics under which QIAGEN will market a range of assays, including a highly sensitive test for Filoviruses (Ebola and Marburg) that is CE IVD-marked for use on QIAGEN instruments and recommended for use with QIAGEN sample technology solutions. QIAGEN is making this test accessible through its commercial networks in many countries around the world, including in Africa.

Maintaining leadership in cervical cancer screening

QIAGEN continues to maintain a solid leadership position in the U.S. market for cervical cancer screening with its digene HC2 Test, despite aggressive pricing actions launched by new competitors in recent years. For the first nine months of 2014, QIAGEN's U.S. sales of HPV products (-35%, 7% of sales) declined in line with previously communicated expectations and created approximately four percentage points of headwind on total adjusted net sales growth. QIAGEN currently expects another decline in U.S. HPV sales in 2015 as a result of new price concessions that are being made during the second half of 2014 as part of customer contract renewals and designed to secure the leading market share for this product. Outside of the U.S., QIAGEN enjoys a solid leadership position for its HPV product portfolio based on its proven superiority in terms of clinical profile. This area provided approximately 4% of total sales in the first nine months of 2014, and is targeting opportunities for further sales expansion in 2015.

Leadership changes in the Executive Committee

Two new members have been named to the QIAGEN Executive Committee:

Dr. Laura Furmanski, Ph.D., has joined QIAGEN in a newly created role as Senior Vice President, Bioinformatics Business Area, to lead our rapidly growing presence in bioinformatics. Dr. Furmanski joined QIAGEN from McKinsey & Company, where she was a partner in the Silicon Valley office and led a broad range of engagements involving med-tech and life science companies. She is based at the QIAGEN Silicon Valley office.

Manuel O. Mendez has joined QIAGEN as Senior Vice President, Global Commercial Operations, to lead QIAGEN’s commercial organizations worldwide. Mr. Mendez was previously with bioMeriéux since 2010, and most recently served as Americas Executive Vice President. He has enjoyed a 25-year career in the diagnostic and life science fields, having also served in leadership positions at OraSure Technologies, Inc., Thermo Fisher Scientific and the Diagnostics Division of Abbott Laboratories, where he worked in positions of increasing responsibility in the U.S., Latin America, Europe, Japan and Korea as well as in global roles. Mr. Mendez has assumed this role following the resignation of Benedikt von Braunmühl, who has decided to pursue other opportunities.

Progress on third $100 million share repurchase program

QIAGEN launched its third $100 million share repurchase program in early August after completion of its second $100 million program in mid-2014. As of October 27, 2014, approximately 1.39 million shares have been repurchased on the Frankfurt Stock Exchange at a volume-weighted average price of EUR 17.82 per share (approximately $22.65 per share at current exchange rates) for a total of EUR 24.7 million (approximately $31.5 million). Repurchased shares will be held in treasury in order to satisfy obligations for exchangeable debt instruments and employee share-based remuneration plans. Information on the progress of the program is available in the Investor Relations section of QIAGEN's website at www.qiagen.com.

2014 outlook

QIAGEN reaffirms its expectations to deliver higher adjusted net sales and adjusted earnings in 2014. For the full year, adjusted net sales are now expected to rise approximately 4% CER (previously 4-5% CER), as sales growth of approximately 8% CER from the current business portfolio, as well as contributions from the bioinformatics acquisitions, are expected to exceed an adverse impact of approximately 4 percentage points from reduced sales of HPV products in the U.S. Adjusted diluted earnings per share (EPS) are now expected to be approximately $1.08 CER (previously $1.07-1.09 CER) compared to $1.02 per share in 2013 (including share-based compensation for both years as part of new adjustment policy). For the fourth quarter of 2014, adjusted net sales are expected to rise approximately 4% CER, with adjusted diluted EPS of $0.33 CER. Based on current exchange rates, adjusted net sales and earnings for full-year 2014 are expected to be adversely affected by certain currency movements against the U.S. dollar, QIAGEN’s reporting currency, and in particular for the fourth quarter of the year. These expectations do not take into account any further acquisitions that could be completed in 2014.

 

New adjustment policy
(Includes SBC costs)

Share-based compensation (SBC) costs

Old adjustment policy
(Excludes SBC costs)

Adjusted EPS
full-year 2013 results

$1.02

$0.12

$1.14

Adjusted EPS
full-year 2014 guidance

$1.08 CER

$0.12 CER

$1.20 CER

 

 

 

 

Adjusted EPS
Q4 2013 results

$0.33

$0.03

$0.36

Adjusted EPS
Q4 2014 guidance

 

$0.33 CER

 

$0.03 CER

 

$0.36 CER

Use of adjusted results

QIAGEN reports adjusted results, as well as results considered on a constant exchange rate basis, and other non-U.S. GAAP figures, to give additional insight into its financial performance. These results include adjusted net sales, adjusted gross profit, adjusted operating income, adjusted net income attributable to owners of QIAGEN N.V., adjusted diluted EPS and free cash flow. Adjusted results are non-GAAP financial measures that QIAGEN believes should be considered in addition to the reported results prepared in accordance with generally accepted accounting principles, but should not be considered as a substitute. Free cash flow is calculated by deducting capital expenditures for Property, Plant & Equipment from cash flow from operating activities. QIAGEN believes certain items should be excluded from adjusted results when they are outside of its ongoing core operations, vary significantly from period to period, or affect the comparability of results with its competitors and its own prior periods. Reconciliations of reported results to adjusted results are included in the tables accompanying this release. QIAGEN has implemented two changes to its presentation of adjusted results starting with results for the first quarter of 2014. Share-based compensation is included as a cost in adjusted results. Information on share-based compensation continues to be disclosed in QIAGEN’s regulatory filings and annual reports. Restructuring costs are also only adjusted for those involving business integration and acquisition-related activities.

Conference call and webcast details

Information on QIAGEN’s performance will be presented during a conference call on Wednesday, October 29, 2014, at 17:00 ET / 21:00 GMT / 22:00 CET. The corresponding presentation slides will be available for download shortly before the event at http://www.qiagen.com/de/about-us/investors/corporate-calendar/. A webcast will also be made available at this website. A replay will also be made available on this website.

About QIAGEN

QIAGEN N.V., a Netherlands-based holding company, is the leading global provider of Sample & Assay Technologies that are used to transform biological materials into valuable molecular information. Sample technologies are used to isolate and process DNA, RNA and proteins from biological samples such as blood or tissue. Assay technologies are then used to make these isolated biomolecules visible and ready for interpretation. QIAGEN markets more than 500 products around the world, selling both consumable kits and automation systems to customers through four customer classes: Molecular Diagnostics (human healthcare), Applied Testing (forensics, veterinary testing and food safety), Pharma (pharmaceutical and biotechnology companies) and Academia (life sciences research). As of September 30, 2014, QIAGEN employed approximately 4,200 people in over 35 locations worldwide. Further information can be found at http://www.qiagen.com.

Certain of the statements contained in this news release may be considered forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. To the extent that any of the statements contained herein relating to QIAGEN's products, markets, strategy or operating results, including without limitation its expected operating results, new product developments, new product launches, regulatory submissions, and financing plans are forward-looking, such statements are based on current expectations and assumptions that involve a number of uncertainties and risks. Such uncertainties and risks include, but are not limited to, risks associated with management of growth and international operations (including the effects of currency fluctuations, regulatory processes and dependence on logistics), variability of operating results and allocations between customer classes, the commercial development of markets for our products in applied testing, personalized healthcare, clinical research, proteomics, women's health/HPV testing and nucleic acid-based molecular diagnostics; changing relationships with customers, suppliers and strategic partners; competition; rapid or unexpected changes in technologies; fluctuations in demand for QIAGEN's products (including fluctuations due to general economic conditions, the level and timing of customers' funding, budgets and other factors); our ability to obtain regulatory approval of our products; difficulties in successfully adapting QIAGEN's products to integrated solutions and producing such products; the ability of QIAGEN to identify and develop new products and to differentiate and protect our products from competitors' products; market acceptance of QIAGEN's new products, the consummation of acquisitions, and the integration of acquired technologies and businesses. For further information, please refer to the discussions in reports that QIAGEN has filed with, or furnished to, the U.S. Securities and Exchange Commission (SEC).

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